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	Provedor de dados Genet. Mol. Biol. (2) Autor Argaraña,Carlos E. (1) Elmula,Imad M. Fadl (1) Fernández,Enrique N. (1) Gallo,Mónica (1) Hamad,Kamal (1) Heller,Viviana B. (1) Ibrahim,Muntaser E. (1) Osman,Emad-Aldin I. (1) Rodríguez,Cecilia M. (1) Sastre,Darío A. (1) Mais... Palavra-chave BCR-ABL (2) Chronic myeloid leukemia (2) Ph chromosome (2) Multiplex-PCR (1) PCR (1) RT-PCR (1) Sudanese (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última An analysis of multiplex-PCR in the detection of BCR-ABL transcripts in hematological disorders Genet. Mol. Biol. Sastre,Darío A.; Argaraña,Carlos E.; Heller,Viviana B.; Gallo,Mónica; Fernández,Enrique N.; Rodríguez,Cecilia M.. In this work, we describe the advantages of multiplex-PCR in the specific detection of BCR-ABL transcripts in different hematological disorders and its sensitivity compared to nested PCR. Fifty-three patients were studied for the presence of BCR-ABL transcripts: 24 patients with chronic myeloid leukemia (CML), 20 with acute leukemia (AL), and 9 patients with other hematological disorders. A variant rearrangement (b3a3) was found in a single case of CML (4.2%). Four out of the 20 patients with AL (20.0%) (14 adults, 6 children) were bcr-abl(+), and in this group three cases were classified as B-acute lymphoblastic leukemia (B-ALL), and one as acute myeloblastic leukemia (AML). Two of the three patients with B-ALL were positive for b2a2 and the other one for... Tipo: Info:eu-repo/semantics/other Palavras-chave: Multiplex-PCR; Ph chromosome; BCR-ABL; Chronic myeloid leukemia; PCR. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400003 Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients Genet. Mol. Biol. Osman,Emad-Aldin I.; Hamad,Kamal; Elmula,Imad M. Fadl; Ibrahim,Muntaser E.. The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in... Tipo: Info:eu-repo/semantics/article Palavras-chave: BCR-ABL; Chronic myeloid leukemia; Ph chromosome; Sudanese; RT-PCR. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005 Registros recuperados: 2 Primeira ... 1 ... Última

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